Understanding Ethionamide: A Comprehensive Overview
Ethionamide, also known as ETA or ETH, is a compound that has garnered significant attention in the pharmaceutical industry. With its unique chemical structure and diverse applications, it is essential to delve into the intricacies of this compound. Let’s explore the various aspects of ethionamide, from its chemical properties to its applications in medicine and research.
Chemical Properties of Ethionamide
Ethionamide is a sulfur-containing derivative of isonicotinamide, which is structurally similar to isoniazid. Its chemical formula is C8H10N2S, and it has a molecular weight of 166.24. The compound is classified as a thioamide and is known for its yellowish color. Ethionamide is available in the form of a powder and is commonly used in ligand binding assays.
| Chemical Properties | Values |
|---|---|
| Empirical Formula | C8H10N2S |
| Molecular Weight | 166.24 |
| Color | Yellow |
| Form | Powder |
Applications of Ethionamide
Ethionamide is primarily used as an antituberculosis drug. It is often prescribed as a second-line treatment when other medications fail to control tuberculosis. Its structure, similar to that of isoniazid, allows it to inhibit the growth of Mycobacterium tuberculosis, the bacterium responsible for causing tuberculosis.
In addition to its use in treating tuberculosis, ethionamide has found applications in various other fields. It is used as an antibacterial agent and is also employed in the determination of the efficacy of compounds against Mycobacterium tuberculosis. Furthermore, ethionamide serves as an antituberculosis antibiotic and an inducer of hypothyroidism.
Manufacturers and Suppliers
Ethionamide is manufactured by several companies, with Sigma-Aldrich being one of the prominent ones. The product is available under the brand name ETA or ETH and is assigned the CAS number 536-33-4. The MDL number for ethionamide is MFCD00057361, and it is also known by the PubChem chemical substance number 24894350. Ethionamide is available in the form of a powder with a purity level of 98.0%.
Storage and Handling
Proper storage and handling of ethionamide are crucial to maintain its efficacy and safety. Ethionamide should be stored at a temperature of 2-8掳C to prevent degradation. It is important to handle the compound with care, as it can be harmful if ingested or inhaled. When working with ethionamide, appropriate personal protective equipment, such as gloves and masks, should be worn.
Additional Information
For further information about ethionamide, you can refer to the data generated by Scripps Metabolomics and Mass Spectrometry Core. The center has generated tandem mass spectrometry data for ethionamide, which can be accessed or downloaded from the provided PDF (E6005.pdf). The Scripps Metabolomics and Mass Spectrometry Core also maintains a METLIN metabolite database, which includes test metabolites. For more details, visit sigma.com/metlin.
In conclusion, ethionamide is a versatile compound with significant applications in medicine and research. Its unique chemical properties and diverse uses make it an essential compound to understand. By exploring its various aspects, we can appreciate the importance of ethionamide in the field of pharmaceuticals.
