Understanding Ethionamide: A Comprehensive Overview
Ethionamide, also known as ETA or ETH, is a compound that has garnered significant attention in the pharmaceutical industry. With its unique chemical structure and diverse applications, it is essential to delve into the intricacies of this compound. Let’s explore the various aspects of ethionamide, from its chemical properties to its applications in medicine and research.
Chemical Properties of Ethionamide
Ethionamide is a sulfur-containing derivative of isonicotinamide, which is structurally similar to isoniazid. Its empirical formula is C8H10N2S, and it has a molecular weight of 166.24. The CAS number for ethionamide is 536-33-4, and it is also known by the EC number 208-628-9 and MDL number MFCD00057361. Ethionamide is available in the form of a yellow powder and is commonly used in ligand binding assays.
Applications of Ethionamide
Ethionamide is primarily used as an antituberculosis drug. It is often prescribed as a second-line treatment when other medications are ineffective. Its structure, similar to that of isoniazid, allows it to inhibit the growth of Mycobacterium tuberculosis, the bacterium responsible for tuberculosis. Ethionamide is also used in biochemical and physiological studies, particularly as an inducer of hypothyroidism.
Usage in Antibacterial Agents and Testing
In addition to its antituberculosis properties, ethionamide is utilized in the development of antibacterial agents. It serves as a valuable tool in testing the efficacy of various compounds against Mycobacterium tuberculosis. This makes ethionamide an essential component in the research and development of new antibiotics.
Chemical Structure and Similarities
The chemical structure of ethionamide is characterized by a 2-ethyl-4-pyridinecarbothioamide group. This structure is similar to that of isoniazid, which is another antituberculosis drug. The similarity in structure allows ethionamide to bind to the same target site as isoniazid, thereby inhibiting the growth of the bacterium. This mechanism of action makes ethionamide an effective treatment option for tuberculosis.
Quality and Storage
Ethionamide is available in high-quality formulations, with a purity level of 鈮?8.0%. It is important to store ethionamide properly to maintain its efficacy. The recommended storage temperature is between 2-8掳C. Storing ethionamide within this temperature range ensures that its chemical properties remain stable and effective.
Availability and Ordering Information
Ethionamide is readily available from reputable manufacturers such as Sigma-Aldrich. The product is available under the SKU E6005. For ordering information, customers can contact the manufacturer at 010-68689484. Ethionamide is also available with a VAT invoice and free shipping, making it convenient for researchers and healthcare professionals to obtain this essential compound.
Additional Information and Resources
For further information on ethionamide, researchers can refer to the data generated by Scripps Metabolomics and Mass Spectrometry Core. The center has generated a comprehensive set of tandem mass spectrometry data, which is available in the PDF E6005.pdf. Additionally, the METLIN metabolite database, hosted by the Scripps Center, contains test metabolites related to ethionamide. For more information, please visit sigma.com/metlin.
Conclusion
Ethionamide is a versatile compound with significant applications in the pharmaceutical industry. Its unique chemical structure and antituberculosis properties make it an essential component in the treatment of tuberculosis. By understanding the various aspects of ethionamide, researchers and healthcare professionals can make informed decisions regarding its use in medicine and research.
